The epic quest to figure out an end to cancer and what that could look like
By American Cancer Society Editors
Cancer is practically as old as life.
Dinosaurs had cancer. Trees get cancer. Right now, all of us have some
cells with the potential to cause cancer, though they usually get
destroyed before becoming a problem.
Scientists
have been on an epic quest to eliminate cancer for centuries, but given
its prevalence, cancer is probably here to stay. “Saying ‘the end of
cancer’ is motivating, but it’s probably not realistic,” says Richard
Wender, MD, chief cancer control officer for the American Cancer Society
(ACS). “It’s an aspirational statement for me. It’s something we work
toward.”
However,
there are other ways to think about the end of cancer: The end of fear
of cancer; the end of pain, suffering, and death from cancer; the end of
cancer as an inevitable disease. Wender points out that up to half of
all cancer deaths could be prevented. And for cancers that can’t be
cured, improved treatments could “enable us to peacefully coexist with
our cancer for a long time,” says Otis Brawley, MD, FACP, ACS chief
medical officer.
In some cancers progress has been significant. The 5-year survival rate for acute lymphoblastic leukemia (ALL),
the most common type of childhood cancer, was about 10% in the early
1960s; now it’s 90%. Several adult cancers, such as testicular cancer
and melanoma, also have a high survival rate. But in other cancers, like
lung and pancreas, progress has been far slower.
Of
course, there’s still much to discover about the causes and mechanisms
of cancer, and we don’t know what we don’t know. Biochemist Bruce
Alberts, PhD, former president of the National Academy of Sciences,
makes the point abundantly clear.
“I
have been writing a cell biology textbook since 1978, so I keep track
of what happens every five years. It’s astounding how ignorant we were
in each previous edition of some of the important aspects of life,”
Alberts says, referring to Molecular Biology of the Cell.
“We used to think cells were containers full of randomly mixed
biological molecules, but nothing could be further from the truth.
Everything inside of a cell is highly organized, and actually in only
the last five years or so have we begun to realize how that works.”
Course correction has always been a part of science, and it ultimately
moves cancer researchers forward on their quest. They follow different
paths: In this publication, we’ll feature some highlights in the areas
of epigenetics, technology, treatment, and prevention — but they’re all working to arrive at the same place: the end of cancer as we know it.
Fonte: Medium Corporation US.
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